Journal: eLife
Article Title: Reproducible, data-driven characterization of sleep based on brain dynamics and transitions from whole-night fMRI
doi: 10.7554/eLife.98739
Figure Lengend Snippet: ( A ) Participants slept inside a scanner from ~23:00 to ~07:00 for two consecutive nights, with concurrent EEG-fMRI recording. During each night, the fMRI experiments were intermittently disrupted by either acoustical arousals (eight random arousals) or spontaneous awakenings. Sleep stages and slow wave density were derived from EEG signals alone. ( B ) Hidden Markov model (HMM) was trained on the principal components of fMRI signals of night 2. Then the identified HMM states were generalized to night 1 fMRI signals. Finally, we studied the state-related variations in fMRI activation, FC patterns, and EEG measures. Notes: EEG, electroencephalographic; TR: repetition time; FC, functional connectivity; ROI, region of interest; PCA, principal component analysis.
Article Snippet: We employed a Gaussian HMM using the Matlab toolbox HMM-MAR v1.0 ( https://github.com/OHBA-analysis/HMM-MAR , copy archived at ), where each state was modeled as a multivariate normal distribution encompassing both first-order statistics (mean activity) and second-order statistics (covariance matrix).
Techniques: Derivative Assay, Activation Assay, Functional Assay